Gel stock solution product description
Carbomer
CAS: 54182-57-9
Molecular Formula:
Gel stock solution product description - Names and Identifiers
| Name | Carbomer |
| Synonyms | Carbomer Karbomer Carbomer 980 940 Gel stock solution product description |
| CAS | 54182-57-9 |
| EINECS | 618-347-7 |
Gel stock solution product description - Physico-chemical Properties
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Carbomer is a loose white powder, acidic, hygroscopic and special odor, soluble in water, ethanol, glycerol. The molecule contains 56% to 58% of a carboxyl group, and thus is weakly acidic. |
| Use | Mainly used as sustained-release materials made of controlled-release drugs, drugs for external use as a carrier matrix |
Gel stock solution product description - Reference
| Reference Show more | 1. Jun Dong. Efficacy of two surgical methods in the treatment of canine glaucoma [J]. 2017. 2. Liu yunkuan, Ma Yunshu, Yan Xian peach, Wang Hongrong, Wang Yan, Cai Junfei. Study on preparation and quality standard of Liuwei Dihuang gel [J]. Modern Chinese medicine research and practice 2020 v.34;No.175(04):52-57. 3. Zhang Xiaozhen, Zhang Dong, Ruan Anmin, Li Huijuan, Chen Pu, Zhou Jun, Ma Yufeng, Qi Yinze, Wang Qingfu. Effect of Tongluo Zhitong gel on p53/miR-502-5p/NF-κBp65 in synovial tissue of KOA [J]. China bone trauma, 2020,33(07):643-648. 4. Zhang Xiaozhen, Zhang Dong, Ma Yufeng, etc. Effect of Tongluo Zhitong gel on rats with knee osteoarthritis [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 034(005):2184-2188. 5. Wu Yumei, Chen Xiaolan, Tang Hongyan, etc. Preparation and quality evaluation of total alkaloids microemulsion gel from Artemisia rupestris in snow [J]. Chinese Journal of Experimental prescriptions, 2016. 6. Xie Weijie, Zhang Yongping, Xu Jian. Screening Matrix formulation of indomethacin hydrophilic gel patch by uniform design [J]. China Pharmacy, 2017(10). 7. Zhu Jinfang, Wu Jing, Ma Qixia, et al. Study on prescription screening and preparation technology of compound horse oil acne cream [J]. Modern Chinese medicine research and practice, 2020(3). 8. Zhang Yongping, Xu Jian, Xie Weijie. Optimization of matrix formulation and molding process of indomethacin hydrophilic gel patch by Central composite design-response surface methodology [J]. Medical leads, 2018, 037(005):593-599. 9. Sun Shuwen, Meng Qingxin, Yan Bo, Yang Yang, Zhang Jia Qi, Zhi Si Jia, Yu ni na. Preparation of Prunella vulgaris gel [J]. Modern Agricultural Science and Technology, 2020(15):230-231 233. 10. Liu yunkuan, Ma Yunshu, Yan Xian peach, Wang Hongrong, Wang Yan, Cai Junfei. Study on preparation and quality standard of Liuwei Dihuang gel [J]. Modern Chinese medicine research and practice, 2020,34(04):48-53. 11. Guo Peixin, Lei Na, Yang Jinyan, Wu Jing, Jie Yuhuan, Xiong Lei. Preparation and safety evaluation of compound Lithospermum emulsion [J]. Journal of Toxicology, 2020,34(05): 431. 12. Chen Pu, Ruan Anmin, Zhou Jun, Zhang Xiaozhen, Ma Yufeng, Yong Chenzhong, Wang Qingpu. Effect of Tongluo Zhitong gel on cartilage inflammation and degeneration in a rabbit model of knee osteoarthritis [J]. Chinese Journal of Tissue Engineering Research, 2021,25(17):2670-2675. 13. Cheng Minggang, Xiao ruorei, Yuan Lianming, Cheng Mengling, Yu Haifeng. Determination of matrine in liposome gel [J]. Journal of Hubei University of Science and Technology (Medical Sciences),2020,34(06):464-466. 14. [IF = 6.953] Yingbei Huang et al."Preparation and evaluation of Bletilla striata polysactride/carboxy methyl chitosan/Carbomer 940 hydrogel for wound healing." Int J Biol Macromol. Jul;132:729 15. [IF = 5.099] Wang Huanhu et al."Antibacterial-based hydrogel dressing containing plant essential oil for burn wound healing." Burns Trau Ma. 2021 Jan;9: 16. [IF = 4.36] Xiangting Sun et al."Evaluation of the wound healing potential of Sophora alopecuroides in SD rat's skin."J Ethnopharmacol. 2021 Jun;273:113998 17. [IF=5.302] Rui Dou et al."Ceramic paste for space stereolithography 3D printing technology in microgravity environment."J Eur Ceram Soc. 2022 Aug;42:3968 18. [IF=6.53] Han Zhang et al."Identification of active compounds and molecular mechanisms of Dalbergia tsoi Merr.et Chun to accelerate wound healing."BIOMEDICINE & PHARMACOTHERAPY. 2022 Jun;150:112990 |
Gel stock solution product description - Standard
Authoritative Data Verified Data
This strain is a high molecular polymer of acrylic acid bonded allyl sucrose or Pentaerythritol allyl ether using a non-benzene solvent as a polymerization solvent. The carboxylic acid group (-COOH) should be 56. 0% to 68. 0% on a dry basis.
Last Update：2024-01-02 23:10:35
Gel stock solution product description - Trait
Authoritative Data Verified Data
This product is a white loose powder; Has a characteristic odor; There is a hygroscopicity.
Last Update：2022-01-01 11:21:45
Gel stock solution product description - Differential diagnosis
Authoritative Data Verified Data
- take o. l g of this product, add 20ml of water and 10% ml of 0.4 sodium hydroxide solution to form a gel.
- take 0. lg of this product, add 10ml of water, shake well, add 0.5M l Thymol blue indicator solution, which should be orange. Take the product 0. lg, add water 1 0 m l, shake, add Cresol red indicator solution 0.5, should be yellow.
- take this product 0. lg, add 10ml of water, adjust the p H value to 7 with lm o l/L sodium hydroxide solution. 5, while stirring the addition of 10% gasified calcium solution 2ml, immediately White precipitation.
- The infrared absorption spectrum of this product (General rule 0402) should be in the wave number of 1710cm-1±5cm-1, 1454cm-1±5cm-1, 1414cm-1 ± ScrrT1, 1245cm-1±5cm-1, 1172cm-1±5 cm-1, there was characteristic absorption at 1115cm-1±5cm -1 and 801cm-1±5 CITT1, with the strongest absorption at 1710cm -1.
Last Update：2022-01-01 11:21:46
Gel stock solution product description - Exam
Authoritative Data Verified Data
acidity
take 0. l g of this product, uniformly disperse and swell in 10ml of water, check according to law (General rule 0631), p H value should be 2. 5~3. 5.
viscosity
take the product l pre-dried at 80°C for 1 hour. O g, add 2 0M l of water with stirring, after uniformly dispersing, adjust p H value to 7 with 15% sodium hydroxide solution. 3 to 7. 8, mix well (to avoid bubbles), in a water bath at 25°C for 1 hour, measured according to law (General 0633), type a should be 4 ~ llP a . s, type B should be 25 to 45Pa · s, and Type C should be 40 to 60Pa · s.
residual solvents benzene, ethyl acetate and cyclohexane
take about 0.2g of this product, precision weighing, top empty bottle, Precision Add dimethyl sulfoxide 5 m l, sealed, as a test solution; Respectively take benzene, the appropriate amount of ethyl acetate and cyclohexane, precision weighing, with dimethyl sulfoxide quantitative dilution of each lm l containing benzene 4 Net, 0.2Mg
And 0.12 mg of the mixed solution, 5ml was accurately measured, placed in a headspace bottle, sealed, and used as a control solution. According to the determination method of residual solvent (General Principle 0861 second method), using 100% dimethyl polysiloxane as stationary liquid (or polar similar stationary liquid) of capillary column, programmed temperature, the initial temperature is 4 0C, maintain 3 minutes, ramp to 120°C at a rate of 5°C per minute for 20 minutes, then ramp to 2 20°C per minute for 3 minutes, then the temperature is raised to 2 4 0°C at a rate of 20°C per minute for 8 minutes; The inlet temperature is 260°C; The detector temperature is 2 60 t:; The equilibrium temperature of the headspace bottle is 85-C, the equilibration time was 90 minutes. The control solution and the test solution were respectively injected in headspace. Based on the peak area calculated by external standard method, benzene shall not be detected, containing ethyl acetate shall not exceed 0.5%, and cyclohexane shall not exceed 0.3%.
acrylic acid
take about 50 m g of this product, weigh it precisely, place it in a centrifugal tube with a plug, and add 2. 5ml of 5% aluminum potassium sulfate solution, cover, shake at 50°C at 250 rpm for 1 hour, centrifuge at 10 000 rpm for 10 minutes, filter, and the filtrate is used as the test solution; take the appropriate amount of acrylic acid control, precision weighing, use 2. The 5% aluminum potassium sulfate solution was dissolved and quantitatively diluted to a solution containing 25pg per 1 μl as a control solution. Determined by high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane was used as filler; Potassium dihydrogen phosphate solution (1.36g of potassium dihydrogen phosphate was taken, 0±0 of water was added to dissolve, and p H value was adjusted to 3-with phosphoric acid. 1 )-formazan (80 : 20) as mobile phase; Detection wavelength 200mn. The lO f J of each of the reference solution and the test solution shall be accurately measured and injected into the liquid chromatograph. The peak area shall be calculated according to the external standard method and shall not exceed 0.25%.
loss on drying
take this product and dry under reduced pressure at 80°C for 1 hour, and the weight loss shall not exceed 0831 (general rule).
ignition residue
This product l .O g, inspection according to law (General 0841), residue shall not exceed 2.0%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:21:47
Gel stock solution product description - Content determination
Authoritative Data Verified Data
take this product about 0. 4G, precision weighing, add water 400ml, stir to dissolve, according to the potential titration method (General rule 0701), with sodium hydroxide titration solution (0. 25mol/L) titration (near the end point, each drop after stirring for at least 2 minutes). Each 1 M l sodium hydroxide titration solution (0.25M o l/L) corresponds to 11. 25mg of one COOH.
Last Update：2022-01-01 11:21:47
Gel stock solution product description - Category
Authoritative Data Verified Data
pharmaceutical excipients, soft matrix and release blockers.
Last Update：2022-01-01 11:21:48
Gel stock solution product description - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:21:48
Gel stock solution product description - Marking
Authoritative Data Verified Data
The viscosity type (type A, type B or type C), viscosity value, instruments and parameters for measuring the product should be indicated.
Last Update：2022-01-01 11:21:48
Gel stock solution product description - Reference Information
| introduction | carbomer (carb0mer) is a high molecular polymer cross-linked with acrylic acid and allyl sucrose or propenyl pentaerythritol. it was first produced by G00drich company in the United States and its trade name is Carb0p01. The 2005 edition of the Chinese Pharmacopoeia has been included. This product is a loose white powder, acidic, hygroscopic and special slightly smelly, soluble in water, ethanol, glycerin. The molecule contains 56% ~ 58% carboxyl groups, so it is weakly acidic. When carbomer is dispersed in water, due to the repulsion between negative charges generated by the ionization of carboxyl groups, the curled polymer stretches out and expands in volume. The pH of the 0.5% aqueous dispersion is 2.7~3.5. The 1% aqueous dispersion can be neutralized with alkaline substances to form a gel. The concentration of commonly used aqueous dispersions is 0.1% ~ 3.0%. |
| pharmacological action | this product is a hydrogel, composed of solid phase (I. e. carbomer) and liquid phase (water) as dispersion medium. Carbomer is a polyacrylic acid polymer cross-linked with pentaerythritol allyl ether or sucrose. Based on its hydrogel properties, this product can adhere to the surface of the cornea and can retain fluid. The structure of the gel will be destroyed by the salt in the tears, releasing the water in it. |
| application | carbomer's main functions are thickening, suspension, emulsification and other functions. it can be used as gel, binder, coating material, rheology improver (humidification agent, lubricant, suspending agent, stabilizer) and so on in pharmacy, and has a wide range of applications, especially in new drug delivery systems. It has been widely used at home and abroad. |
| Overview | Carbomer (carb0mer) is a high molecular polymer cross-linked with acrylic acid and allyl sucrose or propenyl pentaerythritol. It was first produced by G00drich Corporation in the United States. The trade name is Capop (Carb0p01). The 2005 edition of the Chinese Pharmacopoeia has been included. |
| use | is mainly used as a controlled-release drug made of sustained-release materials, and external drugs are used as carrier matrix |
Last Update：2024-04-09 15:16:51
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Featured ProductsSpot supply
Product Name: Carbomer Visit Supplier Webpage Request for quotationCAS: 54182-57-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Carbomer 980 Request for quotationCAS: 54182-57-9
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
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